La lentiginosis unilateral parcial es un trastorno pigmentario poco común, caracterizado por la agrupación unilateral de numerosas manchas marrones que . Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal. Partial unilateral lentiginosis colocalized with naevus depigmentosus. S. I. In. Department of Dermatology, Ajou University School of Medicine.

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There was no family history of similar pigmented lesions or personal history of neurological problems.

Lentiginoosis Upcoming Special Issues. Journal List Case Rep Dermatol v. Over the last few years, the 1,nm Q-switched neodymium-doped yttrium aluminum garnet QS Nd: It is characterized by small, well delimited, hyperchromic macules, distributed in a limited area of the body, which can affect one or more dermatomes and stop at the median line.

Support Center Support Center. Received Apr 5; Accepted May 5. InMcKelway was the first author to study a case of a patient with unilateral distribution of lentigines, but Pickering was first to introduce the term partial unilateral lentigines in [ 59 ].

Lentiginosis unilateral parcial. | Actas Dermo-Sifiliográficas (English Edition)

Dermatology and Dermatologic Diseases. There are reports of PUL associated to a parcizl nervous system disease, such vascular malformation and mental retardation. Disclosure Statement The authors confirm that there are no conflicts of interest. SNIP measures contextual citation impact by wighting citations unllateral on the total number of citations in a subject field.

These nevi should be monitored for ABCDE changes as in any other melanocytic lesion but do not necessitate treatment unless clinically worrisome.


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YAG laser treatment had a subcellular selective photothermolytic effect on a subcellular-specific organelle: This item has received. Request Full-text from Authors.

It is also possible that lentigginosis resulting metabolites from the arachidonic acid pathway and histamine from mast cells may affect melanogenesis [ 14 ], thus resulting in PIH. Introduction Partial unilateral lentiginosis PUL is a rare pigmentary disorder characterized by multiple lentigines grouped within an area of normal skin, often in a segmental pattern [ 1 ].

It is convenient to perform complementary exams which should include routine biochemistry, thyroid profile, FSH and LH, and to refer to evaluations by a Neurologist, Oftalmologista, Cardiologist and Gastroenterologist, in order to detect eventual associations [ 27 ].

Human fibroblasts secrete several melanogenic cytokines, such as bFGF, HGF, and SCF, when they are rapidly growing or during inflammation, which suggests the possibility that overexpression of these cytokines by dermal fibroblasts may activate melanocytes in the overlying epidermis [ 13 ]. Long term prognosis is unknown and the risk of malignant transformation is very low [ 28 ]. If appropriate measures are taken to monitor patient response during and after the procedure, low-fluence 1,nm QS Nd: The left nasal wing presented a surgical scar from the excised melanoma.

These results revealed that low-fluence QS Nd: Therefore, this result can also be interpreted as a selective photothermolytic effect of the laser on mature melanosomes. Author information Article notes Copyright and License information Disclaimer. Partial unilateral lentiginosis PUL is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Conventional high-fluence laser techniques may cause PIH because keratinocytes are injured during the process.

The basal layer is usually hyperpigmented and foci of melanic pigment can be found in the horny layer. Free radical oxygen and peroxide from the keratinocytes also activate melanocytes and increase melanin synthesis in the melanosomes, eventually causing PIH [ 101112 ]. Laser therapy is also effective, as Q-switched Nd: Pickering JG Partial unilateral lentiginosis with associated developmental abnormalities.


Happle R Nevus spilusmaculosus vs. J Am Acad Dermatol. Because mature melanosomes accumulate in the dendrites of melanocytes, the ldntiginosis photothermolytic effect of the laser can be focused intensively on dendrites. Lentigo simplex is a small well-delimited pigmented macula entailed by the presence of an increased number of isolated melanocytes alongside the dermoepidermal junction, mainly at the sides and bases of elongated and thin interpapillary cones.

Partial unilateral lentiginosis with ipsilateral Lisch nodules and axillary freckling. | PubFacts

Br J DermatolSyph National Center for Biotechnology InformationU. Unilatefal melanocytic nevi may be located on the entire half of the body or letniginosis one localized area. No family member had any sign of neurofibromatosis 1.

Article in Pediatr Dermatol Micali G et al. But as treatment was well tolerated without PIH unialteral aggravation of lesions, recurrence may be treated with the same method. There is no established standard treatment for PUL. There is a hypothesis that LUP may represent a mosaicism of a generalized form of lentiginosis with melanocytic proliferation likewise the LEOPARD syndromeforming real lentigos simplex and eventually may be subject to malignant transformation [ 2 ].

YAG laser treatment for melasma [ 15 ]. To present, only one case with family history was reported [ 10 ].